Natural Bioactive Sterol 5α,8α-endoperoxides as Drug Lead Compounds

List of Abbreviations: EP: Ergosterol Peroxide; ERGO: Ergosterol; U266, RPMI-8226, PMI-8226: Multiple Myeloma cell Line; SNU-1: Human Gastric Tumor Cell Line; Hep3B, HepG2, SUN354, BEL-7402, LO2: Human Hepatoma Cell Line; SUN -C4: Human colorectal tumor cell line; HL60, K562, P388, K462: Human Leukaemia Cell Line; DU-145, LNCAP: Human Prostate Cancer Cell line; HT29, COLO-205: Human Colorectal Tumor Cell; HCT-8: Human Colorectal Cancer Cell Line; SF-295: Human Glioblastoma Cancer Cell Line; WM-1341: Human Malignant Melanoma Cell Line; SGC-7901: Human Gastric Adenocarcinoma Cell Line; HeLa: Human Cervical Carcinoma Cancer Cell Line; KB: Human Nasopharyngeal Epidermoid Carcinoma Cell Line; FL: Human Follicular Lymphoma Cell Line; Hep2: Human Epithelial Cancer Cell; HTLV-I: Human T-Cell Leukemia/ Lymphotropic Virus Type I; MCF7WT, MDA-MB-231, MDA-MB435, MCF-7: Human breast cancer cell line; A549: Human Lung Cancer Cell Line; SK-OV-3: Human Ovarian Cancer Cell Line; SK-MEL-2: Human Skin Melanoma Cancer Cell Line; XF498: Human Central Nerve System Cancer Cell Line; HCT15: Human Colic Cancer Cell Line; WI38: Human Lung Fibroblast Cell Line; H37Rv: Mycobacterium tuberculosis; OVCAR-3, OVCAR-8: Ovarian Cancer Cell Line; MOLT-4, Jurkat: Human lymphoid cancer cell line; JAK2: Janus kinase 2; STAT: Signal Transducer and Activator of Transcription; ATCC: American Type Culture Collection; MyD88: Myeloid Differentiation factor 88; VCAM-1: Vascular Cell Adhesion Molecule 1; NF-kB: Nuclear factor kappa B; RAW264.7: Macrophages; C/EBPβ: EnhancerBinding Protein β; p38: Mitogen-activated protein kinase; JNK: Jun N-Terminal Kinase; ERK: Extracellular singal-Regulated Kinase; MAPKs: Mitogen-Activated Protein Kinases; CDKN1A: CyclinDependent Kinase Inhibitor; iNOS: Inducible Nitric Oxide Synthase (enzyme); COX-2: Cyclo-oxygen-ase; PGE2: Prostaglandin E2